Therapeutic
Pipeline

Our
Pipeline

Our
Pipeline

The initial focus is on building a neuro-oncology pipeline for brain metastases of breast and lung cancers, given the advantages involved:
01
This choice allows us to bring approved and effective biologics – which, until now, have only been treating cancer from the neck down – into the brain.

02

Brain metastases are on the rise, given the advanced systemic treatments that enable patients to live longer – but also long enough for their cancers to metastasize to the brain. Once the cancer makes its way to the brain, the prognosis is very poor, with up to 4-6 months survival.

03

The fast-track relevant to drug development for oncology indications will expedite our go-to-market process.

Alongside a portfolio of in-house therapeutic antibodies for neuro-oncology indications, Nanocarry is seeking partnerships with pharma and biotech companies to leverage the AxS platform to co-develop the next generation of therapeutics for patients living with CNS diseases.

A co-development strategy with partners will pave the way for a new era of drug innovation, creating infinite possibilities to go beyond the “shuttle” nature of the AxS platform and leverage it to create multidrug modalities and new mechanisms of action to treat CNS indications for which no biologics are currently approved.

Our Pipeline

Nanocarry’s efficient system for overcoming the restrictive nature of the BBB combines the unique properties of bioengineered gold nanoparticles (GNPs) with the receptor mediated transcytosis, a process naturally occurring in the body when non-restricted molecules pass the BBB. The platform was extensively studied in healthy animals as well as in neurodegenerative disease models and brain tumors.
Check out a sample of our latest research and publications:
  • The effect of nanoparticle size on the ability to cross the blood–brain barrier: an in vivo study
  • In vivo neuroimaging of exosomes using gold nanoparticles
  • In-vitro optimization of nanoparticle-cell labeling protocols for in-vivo cell tracking applications
  • Nanoparticle-based CT imaging technique for longitudinal and quantitative stem cell tracking within the brain: application in neuropsychiatric disorders
  • Advances in imaging strategies for in vivo tracking of exosomes
  • Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier
  • Nanomedicine for cancer immunotherapy: tracking cancer-specific T-cells in vivo with gold nanoparticles & CT imaging
  • Multifunctional dendrimer-entrapped gold nanoparticles for labeling and tracking T cells via dual-modal computed tomography and fluorescence imaging
  • Transport of nanoparticles through the blood–brain barrier for imaging and therapeutic applications
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